منابع مشابه
Borne Identity: Leading Endogenous Suspects at Imidazoline Binding Sites
Over the past few years, a vast amount of research has shed light on the pharmacology of imidazoline binding sites (I-BS). To date, at least three classes of imidazoline binding sites have been characterised in accordance to their localisation, drug selectivity, proposed signalling pathways and functional roles. The existence of these sites raises the question as to whether an endogenous modula...
متن کاملCharacterization of I2 imidazoline and sigma binding sites in the rat and human stomach.
Radioligand binding experiments were carried out to identify and characterize nonadrenoceptor [3H]idazoxan binding sites and [3H](1, 2-di-(2-tolyl)guanidine) binding sites in the rat and human stomach. Furthermore, we examined two selected aspects of their potential functional significance. Binding of [3H]idazoxan (Kd = 11.1 nM and 12.4 nM, respectively) and [3H]DTG (Kd = 932 nM and 242 nM, res...
متن کاملVisualization of multiple imidazoline/guanidinium-receptive sites.
Compounds with an imidazoline or guanidinium moiety elicit a variety of stimulatory and inhibitory cell responses in both central and peripheral tissues. Many of these effects are mediated by interaction with alpha-adrenergic receptors, but these molecules also selectively recognize other membrane-bound proteins with high affinity. We used a functionalized derivative of the imidazoline molecule...
متن کاملCharacterization of I2 Imidazoline and s Binding Sites in the Rat and Human Stomach
Radioligand binding experiments were carried out to identify and characterize nonadrenoceptor [H]idazoxan binding sites and [H](1,2-di-(2-tolyl)guanidine) binding sites in the rat and human stomach. Furthermore, we examined two selected aspects of their potential functional significance. Binding of [H]idazoxan (Kd 5 11.1 nM and 12.4 nM, respectively) and [H]DTG (Kd 5 932 nM and 242 nM, respecti...
متن کاملImidazoline and alpha(2a)-adrenoceptor binding sites in postmenopausal women before and after estrogen replacement therapy.
BACKGROUND Platelet alpha(2A)-adrenoceptors (alpha(2A)AR) and imidazoline binding sites (subtype I(1)) have been proposed as peripheral markers of brain stem receptors that mediate sympathetic outflow and are reported to be elevated in major depression. METHODS In our study, p[(125)I]-iodoclonidine was used to assess platelet alpha(2A)AR and I(1) binding sites in healthy postmenopausal women ...
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ژورنال
عنوان ژورنال: American Journal of Hypertension
سال: 1992
ISSN: 1941-7225,0895-7061
DOI: 10.1093/ajh/5.4.72s